ea0037oc10.3 | Nuclear receptors and signalling | ECE2015
Alonso-Merino Elvira
, Orozco Rosa M Martin
, Llorente Lidia Ruiz
, Martinez-Iglesias Olaia
, Velasco-Martin Juan P
, Fanjul-Rodriguez Luisa F
, Regadera Javier
, Aranda Ana
Fibrosis represents a major health concern and presently has no successful treatment. Chronic liver fibrosis leads to portal hypertension, cirrhosis, hepatocellular carcinoma and liver failure. Transforming growth factor β (TGFβ), the main profibrogenic factor, mediates its actions mainly through activation of Smad transcription factors. We have previously observed a cross-talk between the thyroid hormone receptors (TRs) and the TGFβ pathway by which the thyroid...